The relation between sleep and different forms of memory formation continues to be a relevant topic in our daily life. Sleep has been found to affect cerebellum-dependent procedural memory formation, but it remains to be elucidated to what extent the level of sleep deprivation directly after motor training also influences our ability to store and retrieve memories. Here, we studied the effect of disturbed sleep in mice during two different time-windows, one covering the first four hours following eyeblink conditioning (EBC) and another window following the next period of four hours. Compared to control mice with sleep ad libitum, the percentage of conditioned responses and their amplitude were impaired when mice were deprived of sleep directly after conditioning. This impairment was still significant when the learned EBC responses were extinguished and later reacquired. However, consolidation of eyeblink responses was not affected when mice were deprived later than four hours after acquisition, not even when tested during a different day-night cycle for control. Moreover, mice that slept longer directly following EBC showed a tendency for more conditioned responses. Our data indicate that consolidation of motor memories can benefit from sleep directly following memory formation.

中文翻译：

---

眨眼后立即剥夺睡眠会损害内存整合。

睡眠与不同形式的记忆形成之间的关系仍然是我们日常生活中的一个相关主题。已发现睡眠会影响小脑依赖的程序性记忆的形成，但尚需阐明运动训练后直接剥夺睡眠的程度还会影响我们存储和恢复记忆的能力。在这里，我们研究了在两个不同的时间窗口中小鼠睡眠受到干扰的影响，一个时间窗口涵盖了眨眼调节（EBC）后的前四个小时，另一个时间窗口涵盖了接下来的四个小时。与随意睡眠的对照小鼠相比，当小鼠在调理后直接丧失睡眠时，其条件反应的百分比及其幅度都会受到损害。当学习到的EBC响应消失并随后重新获得时，这种损害仍然很严重。但是，当小鼠在采集后四小时后被剥夺时，即使在不同的昼夜周期进行测试以控制对照时，眨眼反应的合并也不会受到影响。此外，在EBC之后直接睡得更长的小鼠表现出更多条件反应的趋势。我们的数据表明，运动记忆的巩固可以从记忆形成后的睡眠中直接受益。