Cancer immunotherapy shows promising potential in future cancer treatment but unfortunately is clinically unsatisfactory due to the low therapeutic efficacy and the possible severe immunotoxicity. Here we show a combined magnetic hyperthermia therapy (MHT) and checkpoint blockade immunotherapy for both primary tumor ablation and mimetic metastatic tumor inhibition. Monodispersed, high-performance superparamagnetic CoFe2O4@MnFe2O4 nanoparticles were synthesized and used for effective MHT-induced thermal ablation of primary tumors. Simultaneously, numerous tumor-associated antigens were produced to promote the maturation and activation of dendritic cells (DCs) and cytotoxic T cells for effective immunotherapy of distant mimetic metastatic tumors in a tumor-bearing mice model. The combined MHT and checkpoint blockade immunotherapy demonstrate the great potentials in the fight against both primary and metastatic tumors.

中文翻译：

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结合磁热疗和免疫疗法进行原发性和转移性肿瘤治疗。

癌症免疫疗法在未来的癌症治疗中显示出令人鼓舞的潜力，但不幸的是，由于疗效低和可能存在严重的免疫毒性，因此在临床上不能令人满意。在这里，我们显示了针对原发性肿瘤消融和模拟转移性肿瘤抑制的磁热疗（MHT）和检查点封锁免疫疗法的组合。合成了单分散的高性能超顺磁性CoFe2O4 @ MnFe2O4纳米颗粒，并将其用于有效的MHT诱导的原发肿瘤热消融。同时，产生了许多与肿瘤相关的抗原，以促进树突状细胞（DC）和细胞毒性T细胞的成熟和活化，从而在荷瘤小鼠模型中有效免疫治疗远距离模拟转移性肿瘤。