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The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review.
Life Sciences ( IF 6.1 ) Pub Date : 2020-01-14 , DOI: 10.1016/j.lfs.2020.117305
Habib Yaribeygi 1 , Mina Maleki 2 , Thozhukat Sathyapalan 3 , Helia Iranpanah 4 , Hossein M Orafai 5 , Tannaz Jamialahmadi 6 , Amirhossein Sahebkar 7
Affiliation  

Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially among younger adults. There is an unmet need to find new therapeutic targets for the management of diabetes. Vitamin D is a promising target in the pathophysiology of DM, especially since vitamin D deficiency is common in patients with diabetes compared to people without diabetes. Evidence suggests that it can play significant roles in improving peripheral insulin sensitivity and glucose metabolism, however, the exact pathophysiological mechanism is not clarified yet. In this current study, we have reviewed the evidence on the effect of vitamin D in improving insulin resistance via distinct molecular pathways.

中文翻译:

维生素D改善葡萄糖稳态的分子机制:机理综述。

糖尿病(DM)是一种复杂的代谢紊乱,涉及多种有害的分子途径和细胞缺陷,导致生物学环境受到干扰。当前,它是一个全球性的健康问题,其发病率正在上升,尤其是在年轻人中。寻找用于治疗糖尿病的新治疗靶标的需求未得到满足。维生素D是DM病理生理的有希望的靶标,特别是因为与没有糖尿病的人相比,糖尿病患者常见维生素D缺乏症。有证据表明它可以在改善周围胰岛素敏感性和葡萄糖代谢中发挥重要作用,但是,尚不清楚确切的病理生理机制。在本研究中,
更新日期:2020-01-15
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