当前位置: X-MOL 学术Pharmacol. Therapeut. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Antifungal effects of statins.
Pharmacology & Therapeutics ( IF 13.5 ) Pub Date : 2020-01-15 , DOI: 10.1016/j.pharmthera.2020.107483
Alireza Tavakkoli 1 , Thomas P Johnston 2 , Amirhossein Sahebkar 3
Affiliation  

Fungal infections are estimated to be responsible for 1.5 million deaths annually. Global anti-microbial resistance is also observed for fungal pathogens, and scientists are looking for new antifungal agents to address this challenge. One potential strategy is to evaluate currently available drugs for their possible antifungal activity. One of the suggested drug classes are statins, which are commonly used to decrease plasma cholesterol and reduce cardiovascular risk associated with low density lipoprotein cholesterol (LDL-c). Statins are postulated to possess pleiotropic effects beyond cholesterol lowering; improving endothelial function, modulating inflammation, and potentially exerting anti-microbial effects. In this study, we reviewed in-vitro and in-vivo studies, as well as clinical reports pertaining to the antifungal efficacy of statins. In addition, we have addressed various modulators of statin anti-fungal activity and the potential mechanisms responsible for their anti-fungal effects. In general, statins do possess anti-fungal activity, targeting a broad spectrum of fungal organisms including human opportunistic pathogens such as Candida spp. and Zygomycetes, Dermatophytes, alimentary toxigenic species such as Aspergillus spp., and fungi found in device implants such as Saccharomyces cerevisiae. Statins have been shown to augment a number of antifungal drug classes, for example, the azoles and polyenes. Synthetic statins are generally considered more potent than the first generation of fungal metabolites. Fluvastatin is considered the most effective statin with the broadest and most potent fungal inhibitory activity, including fungicidal and/or fungistatic properties. This has been demonstrated with plasma concentrations that can easily be achieved in a clinical setting. Additionally, statins can potentiate the efficacy of available antifungal drugs in a synergistic fashion. Although only a limited number of animal and human studies have been reported to date, observational cohort studies have confirmed that patients using statins have a reduced risk of candidemia-related complications. Further studies are warranted to confirm our findings and expand current knowledge of the anti-fungal effects of statins.

中文翻译:

他汀类药物的抗真菌作用。

据估计,每年真菌感染可导致150万人死亡。还观察到了真菌病原体的全球抗药性,科学家正在寻找新的抗真菌剂来应对这一挑战。一种潜在的策略是评估目前可用的药物可能的抗真菌活性。建议的药物类别之一是他汀类药物,通常用于降低血浆胆固醇和降低与低密度脂蛋白胆固醇(LDL-c)相关的心血管风险。他汀类药物被认为具有降低胆固醇以外的多效作用。改善内皮功能,调节炎症,并可能发挥抗微生物作用。在这项研究中,我们回顾了体外和体内研究以及有关他汀类药物抗真菌功效的临床报告。此外,我们已经解决了他汀类药物抗真菌活性的各种调节剂以及引起其抗真菌作用的潜在机制。通常,他汀类药物确实具有抗真菌活性,靶向多种真菌生物,包括人类机会性病原体,例如念珠菌。在植物植入物中发现的真菌和酵母菌,皮肤真菌,消化性产毒物种(如曲霉属)和真菌。他汀类药物已显示出增加了许多抗真菌药物的种类,例如唑类和多烯类。通常认为合成他汀类药物比第一代真菌代谢物更有效。氟伐他汀被认为是最有效的他汀类药物,具有最广泛和最有效的真菌抑制活性,包括杀真菌和/或抑真菌特性。血浆浓度可以在临床环境中轻松实现这一点。另外,他汀类药物可以以协同方式增强可用的抗真菌药物的功效。尽管迄今仅报道了有限的动物和人体研究,但观察性队列研究已证实,使用他汀类药物的患者与念珠菌血症相关并发症的风险降低。有必要做进一步的研究以证实我们的发现,并扩大他汀类药物抗真菌作用的最新知识。观察性队列研究证实,使用他汀类药物的患者与念珠菌血症相关并发症的风险降低。有必要做进一步的研究以证实我们的发现,并扩大他汀类药物抗真菌作用的最新知识。观察性队列研究证实,使用他汀类药物的患者与念珠菌血症相关并发症的风险降低。有必要做进一步的研究来证实我们的发现,并扩大有关他汀类药物抗真菌作用的最新知识。
更新日期:2020-01-15
down
wechat
bug