Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease (IBD) that may be marked by debilitating symptoms of abdominal pain and obstruction. The etiology and pathogenesis of the disease are not fully understood, and treatment with corticosteroids, biologics, and surgical intervention are the usual therapeutic options. Diagnosis, disease activity, and therapeutic response are currently assessed by endoscopy, cross-sectional imaging, and biomarkers. However, challenges remain regarding the efficacy of the drugs and safety of these imaging techniques. There are also limitations with current clinical and laboratory tools for diagnosis, disease progression, and treatment response. Here, we discuss how the integration of proteomics and activity-based probes, along with intestinal ultrasound, an easily repeatable and well-tolerated diagnostic imaging modality, can address these challenges and may provide a novel precision medicine-based approach for the treatment of CD.

中文翻译：

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克罗恩病的蛋白质组学和成像：不太可能的盟友的尾巴。

克罗恩病 (CD) 是一种慢性复发性炎症性肠病 (IBD)，其特征可能是腹痛和梗阻的虚弱症状。该疾病的病因和发病机制尚不完全清楚，皮质类固醇、生物​​制剂和手术干预是通常的治疗选择。目前通过内窥镜检查、横断面成像和生物标志物来评估诊断、疾病活动和治疗反应。然而，在药物的功效和这些成像技术的安全性方面仍然存在挑战。当前用于诊断、疾病进展和治疗反应的临床和实验室工具也存在局限性。在这里，我们讨论蛋白质组学和基于活性的探针的整合以及肠道超声，