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Superacid-promoted synthesis of quinoline derivatives
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2020-01-14 , DOI: 10.1016/j.tetlet.2020.151630
Hien Vuong , Michael R. Stentzel , Douglas A. Klumpp

A series of vinylogous imines have been prepared from anilines and cinnamaldehydes. These substrates react in superacidic media to provide quinolines and related compounds. A mechanism for the conversion is proposed which involves the cyclization of dicationic superelectrophilic intermediates. Aromatization of the quinoline ring is thought to occur by superacid-promoted elimination of benzene.



中文翻译:

超强酸促进喹啉衍生物的合成

从苯胺和肉桂醛制备了一系列乙烯基亚胺。这些底物在超酸性介质中反应以提供喹啉和相关化合物。提出了一种转化机理,该机理涉及双阳离子超亲电中间体的环化。认为喹啉环的芳香化是通过超酸促进的苯消除而发生的。

更新日期:2020-01-15
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