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Multifarious Fabrication Approaches of Producing Aligned Collagen Scaffolds for Tissue Engineering Applications
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2020-01-14 , DOI: 10.1021/acsbiomaterials.9b01225
Ankush Dewle 1 , Navanit Pathak 1 , Prakash Rakshasmare 1 , Akshay Srivastava 1
Affiliation  

Aligned tissue architecture is a basic proviso for several organs and tissues like intervertebral discs, tendons, ligaments, muscles, and neurons, which comprises type-I collagen as an eminent extracellular matrix (ECM) protein. Exploiting type-I collagen for the biofabrication of aligned constructs via different approaches is becoming apparent, as it comprises a major fraction of connective tissue, exhibits abundance in ECM, and displays poor antigenicity and immunogenicity, along-with the ease of remodelling adaptability. Collagen hydrogels or composite scaffolds with uniaxial fibril alignment or unidirectional pore architecture having different sizes and densities are being fabricated using electrical, mechanical, and freeze-drying processes which are applicable for tissue engineering and regenerative purposes. This review focuses on several multifarious approaches employed to fabricate anisotropic structures of type-I collagen which influences fibril alignment, pore architecture, stiffness anisotropy, and enhanced mechanical strength and mimics the tissue native microenvironment ushering cell niches to proliferate and differentiate into tissue specific lineages.

中文翻译:

生产用于组织工程应用的对齐胶原蛋白支架的多种制造方法

对齐的组织结构是几个器官和组织(如椎间盘,肌腱,韧带,肌肉和神经元)的基本条件,其中包含I型胶原蛋白作为突出的细胞外基质(ECM)蛋白。通过不同的方法开发I型胶原蛋白以用于生物合成排列的构建物变得很明显,因为它包含大部分结缔组织,在ECM中表现出丰富的抗原性和免疫原性,以及易于重塑的适应性。使用电气,机械和冷冻干燥工艺制造具有不同尺寸和密度的具有单轴原纤维排列或单向孔结构的胶原蛋白水凝胶或复合支架,所述工艺适用于组织工程和再生目的。
更新日期:2020-01-14
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