Metal/silica nanoparticles (NPs) have long been used as antibacterial substitutes; however, fabrication of a degradable carrier for achieving sustained release profile, high bactericidal efficacy, and good biocompatibility is still a challenge. Herein, we fabricated nanosilver-decorated biodegradable mesoporous organosilica nanoparticles (MONs) using a biocompatible natural polyphenol, tannic acid (TA), as not only a nonsurfactant template to form MONs but also a reducible agent to generate nanosilvers. Such a straightforward and green one-pot method does not need prior synthesis of silver NPs, removal of template, and use of toxic reducing agents. The resulting Ag-MONs with a well-distributed nanosilver exhibited a matrix-degradation-based silver ions release in response to glutathione (GSH), resulting in a stronger antibacterial effect with nondegradable Ag-mesoporous silica nanoparticles (MSNs), Ag NPs, and silver nitrate on Escherichia coli and Staphylococcus aureus. Moreover, Ag-MONs show better biocompatibility than the Ag NPs and silver nitrate at the same silver dose. Our findings have provided a facile and economical route to fabricate nanosilver-decorated biodegradable mesoporous organosilica nanoparticles. These nanoparticles showed promising applications in the fields of biomedicine and catalysis.

中文翻译：

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单宁酸辅助合成的纳米银修饰的可生物降解和抗菌的介孔有机硅纳米粒子

金属/二氧化硅纳米颗粒（NPs）长期以来一直被用作抗菌替代品。然而，制造可降解载体以实现持续释放特性，高杀菌效力和良好的生物相容性仍然是一个挑战。本文中，我们使用生物相容性天然多酚鞣酸（TA）制备了纳米银修饰的可生物降解的介孔有机二氧化硅纳米粒子（MONs），不仅作为形成MONs的非表面活性剂模板，而且还作为生成纳米银的可还原剂。这种简单，绿色的一锅法不需要事先合成银纳米颗粒，去除模板并使用有毒的还原剂。所得的具有均匀分布的纳米银的Ag-MONs响应谷胱甘肽（GSH）释放出基于基质降解的银离子，大肠杆菌和金黄色葡萄球菌。此外，在相同的银剂量下，Ag-MONs比Ag NPs和硝酸银具有更好的生物相容性。我们的发现为制备纳米银修饰的可生物降解的介孔有机二氧化硅纳米粒子提供了一种简便而经济的途径。这些纳米颗粒在生物医学和催化领域显示出有希望的应用。