当前位置: X-MOL 学术JAMA › 论文详情
Recommendations Related to Genetic Testing for Breast Cancer.
JAMA ( IF 45.540 ) Pub Date : 2020-01-14 , DOI: 10.1001/jama.2019.18217
Paul F Pinsky

To the Editor The recent Recommendation Statement by the US Preventive Services Task Force (USPSTF)1 on risk assessment, genetic counseling, and genetic testing for breast cancer susceptibility (BRCA) gene mutations seems to contain some internal inconsistencies. The Summary of Recommendations and Evidence section stated that women with either a personal or family history of BRCA-related cancers or an ancestry associated with BRCA mutations are recommended for risk assessment. However, in the USPSTF Assessment section, net benefit of the intervention was only ascribed to women with the relevant family or personal history, and it was stated that the harms of risk assessment outweigh the benefits “in women whose family or personal history is not associated with an increased risk” for harmful BRCA mutations. Therefore, the task force appears to be recommending intervention for women with a BRCA-associated ancestry but no personal or family history (since such women satisfy the “or” logic in the recommendation) but also stating that the harms outweigh the benefits for these women. Another sentence in the text, under Estimate of Magnitude of Net Benefit, excluded even personal history, stating that the harms of risk assessment outweigh the benefits for women without a BRCA-associated family history. Although readers could presume that the task force would consider these interventions to have net benefit in women with the requisite ancestry but no relevant family or personal history, it is curious that these direct statements would exclude mention of ancestry. It would be helpful if the task force could provide added clarity with regard to these net benefit statements and their relation to the overall recommendation.

更新日期:2020-01-14

 

全部期刊列表>>
施普林格自然
最近合集,配们化学
欢迎访问IOP中国网站
GIANT
自然职场线上招聘会
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
何川
苏昭铭
陈刚
姜涛
李闯创
复旦大学
刘立明
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
天合科研
x-mol收录
上海纽约大学
曾林
天津大学
何振宇
史大永
吉林大学
卓春祥
张昊
刘冬生
试剂库存
down
wechat
bug