OBJECTIVES Clinical studies show that resistance exercise and a protein-rich diet can counteract the age-related decline of muscle mass, strength, and physical performance. The aim of the ProMuscle in Practice study was to test effectiveness of a resistance exercise and dietary protein intervention for older adults implemented in a real-life setting. DESIGN A randomized controlled multicenter intervention study. SETTING AND PARTICIPANTS One hundred sixty-eight community-dwelling older adults were included (age 75 ± 6 years). A 12-week intensive support intervention including progressive resistance exercise supervised by a physiotherapist and dietitian guidance on increasing protein intake was followed by a voluntary 12-week moderate support intervention to continue the adapted lifestyle pattern. The control group received no intervention. METHODS Compliance was measured through attendance lists and 3-day food records. Physical functioning, leg strength (3-repetition maximum, knee extension strength), lean body mass [(LBM) dual-energy X-ray absorptiometry], and quality of life (5-level EQ-5D) were measured at baseline, and after 12 and 24 weeks. Differences in change between groups were assessed with linear mixed model analysis. RESULTS The intervention group increased protein intake and attended 83.6% of the training sessions. Short Physical Performance Battery score slightly increased in intervention participants [from 10.1 (95% confidence interval 9.7-10.5) to 10.4 (10.0-10.8) at week 12 and 10.6 (10.2-10.9) at week 24], where control participants decreased (time × treatment interactions, P < .05). Improvements in intervention group compared with controls were also observed for Timed Up-and-Go, strength and LBM at both time points (time × treatment interactions, P < .05). No difference between groups was found for the 6-Minute Walking Test, activities of daily living, and quality of life. CONCLUSIONS AND IMPLICATIONS ProMuscle in Practice was effective on improving muscle strength and LBM, with small changes in the composite function score in community-dwelling older adults in a real-life setting. Further research should explore feasibility of real-life implementation, as well as improving long-term compliance.

中文翻译：

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饮食和抗阻运动干预对老年人肌肉健康的有效性：ProMuscle 在实践中

目的 临床研究表明，抗阻运动和富含蛋白质的饮食可以抵消与年龄相关的肌肉质量、力量和身体机能下降。ProMuscle in Practice 研究的目的是测试在现实生活环境中对老年人实施的抗阻运动和膳食蛋白质干预的有效性。设计 一项随机对照多中心干预研究。设置和参与者 包括 168 名居住在社区的老年人（年龄 75 ± 6 岁）。为期 12 周的强化支持干预包括在物理治疗师和营养师指导下进行的渐进式抗阻运动，以增加蛋白质摄入量，然后进行为期 12 周的自愿适度支持干预，以继续适应后的生活方式。对照组不接受干预。方法 通过出席名单和 3 天的食物记录来衡量依从性。在基线测量身体机能、腿部力量（最大重复 3 次，膝盖伸展强度）、瘦体重 [（LBM）双能 X 射线吸收测定法] 和生活质量（5 级 EQ-5D），以及12 周和 24 周后。使用线性混合模型分析评估组间变化的差异。结果 干预组增加了蛋白质摄入量并参加了 83.6% 的培训课程。干预参与者的短期身体表现电池得分略有增加 [从第 12 周的 10.1（95% 置信区间 9.7-10.5）到 10.4（10.0-10.8）和第 24 周的 10.6（10.2-10.9）]，其中对照组参与者减少（ × 治疗相互作用，P < .05)。与对照组相比，干预组在两个时间点的 Timed Up-and-Go、力量和 LBM 都有改善（时间 × 治疗相互作用，P < .05）。在 6 分钟步行测试、日常生活活动和生活质量方面没有发现组间差异。结论和意义 ProMuscle in Practice 可有效改善肌肉力量和 LBM，在现实生活环境中，社区老年人的综合功能评分变化很小。进一步的研究应该探索现实生活中实施的可行性，以及提高长期合规性。结论和意义 ProMuscle in Practice 可有效改善肌肉力量和 LBM，在现实生活环境中，社区老年人的综合功能评分变化很小。进一步的研究应该探索现实生活中实施的可行性，以及提高长期合规性。结论和意义 ProMuscle in Practice 可有效改善肌肉力量和 LBM，在现实生活环境中，社区老年人的综合功能评分变化很小。进一步的研究应该探索现实生活中实施的可行性，以及提高长期合规性。