Poly(dimethylsiloxane) (PDMS) has been widely used in the field of microfluidics, optical systems, and sensors. However, the hydrophobic nature of PDMS leads to low surface wettability and biofouling problems due to the nonspecific proteins-hydrophobic surface interactions and cell/bacterial adhesion. In this work, the PDMS surface was first introduced with amino groups (PDMS-NH2) via KOH-catalyzed reaction with 3-aminopropyltriethoxysilane (APTES). The PDMS-NH2 was then grafted with poly(N-vinylpyrrolidone) (PVP) based on the self-adhesion reaction between the amino surface and catechol-functionalized PVP (CA-PLL-PVP). CA-PLL-PVP as a comb-polymer was synthesized by conjugating PVP-COOH along with caffeic acid to the ε-polylysine backbone. A significantly enhanced water wettability was observed with contact angles dropped from 116° to 14° after coating with CA-PLL-PVP. The coated surface demonstrated excellent antifouling performance that no appreciable Staphylococcus epidermidis biofilm formation could be observed. This novel facile antifouling coating on PDMS surface may find greater biomedical applications to eliminate the potential adherence problems caused by natural biofouling.

中文翻译：

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聚（N-乙烯基吡咯烷酮）在聚（二甲基硅氧烷）上的表面功能化，以用于抗生物膜应用。

聚（二甲基硅氧烷）（PDMS）已被广泛用于微流体，光学系统和传感器领域。然而，由于非特异性蛋白质-疏水性表面相互作用和细胞/细菌粘附，PDMS的疏水性导致低的表面润湿性和生物污染问题。在这项工作中，PDMS表面首先通过KOH催化与3-氨丙基三乙氧基硅烷（APTES）的反应引入了氨基（PDMS-NH2）。然后根据氨基表面和邻苯二酚官能化的PVP（CA-PLL-PVP）之间的自粘反应，将PDMS-NH2接枝聚（N-乙烯基吡咯烷酮）（PVP）。CA-PLL-PVP为梳状聚合物，是通过将PVP-COOH和咖啡酸与ε-聚赖氨酸骨架缀合而合成的。在用CA-PLL-PVP涂层后，观察到的水润湿性显着提高，接触角从116°降至14°。涂层表面显示出优异的防污性能，未观察到明显的表皮葡萄球菌生物膜形成。PDMS表面上这种新颖的防污涂料可能会发现更多的生物医学应用，以消除由自然生物污垢引起的潜在粘附问题。