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Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids.
Metabolites ( IF 4.1 ) Pub Date : 2020-01-14 , DOI: 10.3390/metabo10010034
Arnaud Germain 1 , Dinesh K Barupal 2 , Susan M Levine 2 , Maureen R Hanson 2
Affiliation  

The latest worldwide prevalence rate projects that over 65 million patients suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), an illness with known effects on the functioning of the immune and nervous systems. We performed an extensive metabolomics analysis on the plasma of 52 female subjects, equally sampled between controls and ME/CFS patients, which delivered data for about 1750 blood compounds spanning 20 super-pathways, subdivided into 113 sub-pathways. Statistical analysis combined with pathway enrichment analysis points to a few disrupted metabolic pathways containing many unexplored compounds. The most intriguing finding concerns acyl cholines, belonging to the fatty acid metabolism sub-pathway of lipids, for which all compounds are consistently reduced in two distinct ME/CFS patient cohorts. We compiled the extremely limited knowledge about these compounds and regard them as promising in the quest to explain many of the ME/CFS symptoms. Another class of lipids with far-reaching activity on virtually all organ systems are steroids; androgenic, progestin, and corticosteroids are broadly reduced in our patient cohort. We also report on lower dipeptides and elevated sphingolipids abundance in patients compared to controls. Disturbances in the metabolism of many of these molecules can be linked to the profound organ system symptoms endured by ME/CFS patients.

中文翻译:

ME / CFS中的综合循环代谢组学揭示了酰基脂质和类固醇的破坏性代谢。

最新的全球患病率预测,超过6500万患者患有肌病性脑脊髓炎/慢性疲劳综合症(ME / CFS),这种疾病会对免疫和神经系统的功能产生已知影响。我们对52名女性受试者的血浆进行了广泛的代谢组学分析,在对照组和ME / CFS患者之间进行了平均采样,从而提供了跨越20种超级途径,细分为113个子途径的约1750种血液化合物的数据。统计分析与途径富集分析相结合,指出了一些含有许多未开发化合物的代谢途径中断。最有趣的发现涉及酰基胆碱,其属于脂质的脂肪酸代谢子途径,在两个不同的ME / CFS患者队列中,所有化合物均被一致地还原。我们汇编了关于这些化合物的极其有限的知识,并认为它们在解释许多ME / CFS症状方面很有希望。在几乎所有器官系统上都有深远影响的另一类脂质是类固醇。在我们的患者队列中,雄激素,孕激素和皮质类固醇的含量大大降低。我们还报告了与对照组相比,患者的二肽含量较低,鞘脂含量较高。这些分子中许多分子的代谢紊乱可能与ME / CFS患者所忍受的深刻器官系统症状有关。并且在我们的患者队列中皮质类固醇激素大量减少。我们还报告了与对照组相比,患者的二肽含量较低,鞘脂含量较高。这些分子中许多分子的代谢紊乱可能与ME / CFS患者所忍受的深刻器官系统症状有关。并且在我们的患者队列中皮质类固醇激素大量减少。我们还报告了与对照组相比,患者的二肽含量较低,鞘脂含量较高。这些分子中许多分子的代谢紊乱可能与ME / CFS患者所忍受的深刻器官系统症状有关。
更新日期:2020-01-14
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