Traditional hydrogel dressings are limited in practical applications due to the complexity of the preparation and low biocompatibility. So, there is an urgent need to design wound dressing with simple preparation method, higher biocompatibility, and superior therapeutic effect. Additionally, using a polysaccharide/protein mixture system is an attractive method to prepare the gel. In this study, a simple mixture of hyaluronic acid/lysozyme (HL) was used to obtain the HL coacervate gel. HL coacervate has suitable viscoelasticity and excellent adhesion on the skin tissue. We demonstrated its highly efficient self-healing property to overcome fracture or deformation. HL coacervate showed a significant effect on promoting wound healing in a full-thickness skin defect model. Compared to the commercial 3M dressing, it has faster epithelial tissue regeneration and stronger collagen deposition. In addition, cytotoxicity and organ toxicity tests indicated its high safety. In summary, HL coacervate has broad clinical application prospects as a wound dressing material.

中文翻译：

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透明质酸/溶菌酶自组装凝聚层，促进皮肤伤口愈合。

由于制备的复杂性和低的生物相容性，传统的水凝胶敷料在实际应用中受到限制。因此，迫切需要设计一种制备方法简单，生物相容性较高，治疗效果好的伤口敷料。另外，使用多糖/蛋白质混合物系统是制备凝胶的有吸引力的方法。在这项研究中，透明质酸/溶菌酶（HL）的简单混合物用于获得HL凝聚层凝胶。HL凝聚层具有合适的粘弹性和在皮肤组织上的优异粘附性。我们展示了其高效的自我修复性能，可以克服断裂或变形。HL凝聚层在全层皮肤缺损模型中显示出显着的促进伤口愈合的作用。与商用3M敷料相比，它具有更快的上皮组织再生和更强的胶原蛋白沉积。另外，细胞毒性和器官毒性测试表明其高度安全性。总之，HL凝聚层作为伤口包扎材料具有广阔的临床应用前景。