Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), has attracted great attention because it can effectively inhibit the proliferation and propagation of cancer cells. Recently, heterojunction nanomaterials have shown tremendous application value in the field of biological medicine. In this work, the CeVO₄/Au heterojunction nanocrystals (NCs) are designed for photothermal/photoacoustic bimodal imaging-guided phototherapy. The as-synthesized hydrophobic oleic acid (OA)-stabilized CeVO₄ nanosheets were modified with HS-PEG-OH for translating into hydrophilic ones, which can significantly improve their stability and biocompatibility. Subsequently, the plasmonic Au nanoparticles were in situ successfully deposited on the surface of HS-PEG-coated CeVO₄ to form CeVO₄/Au heterojunction NCs for improving the visible and near-infrared light absorption, which results in enhanced photothermal conversion performance and reactive oxygen species (ROS) generation capacity. Thus, the CeVO₄/Au can cause more severe damage to cancer cells than pure CeVO₄ under NIR laser irradiation. Also, CeVO₄/Au can provide distinct tumor contrast by photothermal/photoacoustic bimodal bioimaging. Our results demonstrate that CeVO₄/Au NCs could be used as an effective theranostic anticancer agent for near-infrared (NIR) light-mediated PTT and PDT.

中文翻译：

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用于光热/光声双模成像引导光疗的自组装CeVO4/Au异质结纳米晶

光疗法，包括光热疗法（PTT）和光动力疗法（PDT），因其能有效抑制癌细胞的增殖和传播而受到高度关注。近年来，异质结纳米材料在生物医学领域显示出巨大的应用价值。在这项工作中，CeVO ₄ /Au异质结纳米晶体（NC）被设计用于光热/光声双模成像引导光疗。将合成的疏水性油酸（OA）稳定的CeVO ₄纳米片用HS-PEG-OH修饰转化为亲水性纳米片，可以显着提高其稳定性和生物相容性。随后，等离激元Au纳米粒子成功原位沉积在HS-PEG涂层的CeVO ₄表面，形成CeVO ₄ /Au异质结NCs，以改善可见光和近红外光吸收，从而增强光热转换性能和反应活性。氧物质（ROS）产生能力。因此，CeVO _{4 /Au在近红外激光照射下比纯CeVO 4}对癌细胞造成更严重的损伤。此外，CeVO ₄ /Au 可以通过光热/光声双模生物成像提供明显的肿瘤对比度。我们的结果表明，CeVO ₄ /Au NCs 可用作近红外（NIR）光介导的 PTT 和 PDT 的有效治疗诊断抗癌剂。