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Ratiometric Detection of Amyloid-beta Aggregation by a Dual-Emissive Tris-heteroleptic Ruthenium Complex
Chemical Communications ( IF 6.164 ) Pub Date : 2020-01-14 , DOI: 10.1039/c9cc08909h
Jiang-Yang Shao; Si-Hai Wu; junjie Ma; Zhong-Liang Gong; Tian-Ge Sun; Yulong Jin; Rong Yang; Bin Sun; Yu-Wu Zhong

A dual-emissive tris-heteroleptic ruthenium complex is designed, synthesized and applied for the ratiometric photoluminescent detection of Amyloid-beta (A-beta) aggregation in both steady and transient states. The A-beta aggregation is supported by transmission electron microscopy and confocal laser scanning microscopy analysis. In addition, molecular docking calculations have been performed to gain insights into the interaction mode between the ruthenium complex and A-beta fibrils.
更新日期:2020-01-14

 

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