BACKGROUND The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of this multicenter prospective observational cohort study was to evaluate lung transplantation outcomes in Korean Organ Transplantation Registry (KOTRY) patients for whom ECMO was used as a bridge to transplantation. METHODS Between March 2015 and December 2017, a total of 112 patients received lung transplantation and were registered in the KOTRY, which is a prospective, multicenter cohort registry. The entire cohort was divided into two groups: the control group (n = 85, 75.9%) and bridge-ECMO group (n = 27, 24.1%). RESULTS There were no significant differences in pre-transplant and intraoperative characteristics except for poorer oxygenation, more ventilator use, and longer operation time in the bridge-ECMO group. The prevalence of primary graft dysfunction at 0, 24, 48, and 72 h after transplantation did not differ between the two groups. Although postoperative hospital stays were longer in the bridge-ECMO group than in the control group, hospital mortality did not differ between the two groups (25.9% vs. 13.3%, P = 0.212). The majority of patients (70.4% of the bridge-ECMO group and 77.6% of the control group) were discharged directly to their homes. Finally, the use of ECMO as a bridge to lung transplantation did not significantly affect overall survival and graft function. CONCLUSIONS Short- and long-term post-transplant outcomes of bridge-ECMO patients were comparable to recipients who did not receive ECMO.

中文翻译：

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体外膜氧合作用为肺移植的桥梁：韩国器官移植登记系统（KOTRY）数据分析。

背景技术体外膜充氧（ECMO）作为通向肺移植的桥梁已大大增加。但是，缺乏有关这种方法的临床结果的数据。这项多中心前瞻性观察队列研究的目的是评估韩国器官移植登记处（KOTRY）患者的肺移植结局，他们将ECMO用作移植的桥梁。方法在2015年3月至2017年12月期间，共有112例患者接受了肺移植，并在前瞻性，多中心队列注册中心KOTRY中进行了注册。整个队列分为两组：对照组（n = 85，75.9％）和桥式ECMO组（n = 27，24.1％）。结果桥式ECMO组除氧合差，使用呼吸机较多，手术时间更长外，在移植前和术中特征上无显着差异。两组在移植后0、24、48和72小时的原发性移植物功能障碍患病率无差异。尽管bridge-ECMO组的术后住院时间长于对照组，但两组的住院死亡率无差异（25.9％vs. 13.3％，P = 0.212）。大多数患者（桥接ECMO组为70.4％，对照组为77.6％）直接出院。最后，使用ECMO作为通向肺移植的桥梁并没有显着影响总体存活率和移植功能。