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Prevalence and associated risk factors of dry eye disease in 16 northern West bank towns in Palestine: a cross-sectional study.
BMC Ophthalmology ( IF 2 ) Pub Date : 2020-01-13 , DOI: 10.1186/s12886-019-1290-z
Yousef Shanti 1, 2 , Reham Shehada 2, 3 , May M Bakkar 4 , Jamal Qaddumi 5
Affiliation  

BACKGROUND Dry Eye Disease (DED) is a multifactorial disease of the interpalpebral ocular surface and tear film that leads to discomfort, fatigue and disturbance in vision. DED affects patients' quality of life and leads eventually to decrease of productivity. Moreover, it has a considerable socioeconomic burden. It is a growing underdiagnosed health issue and the possible associated risk factors are very common and keep growing worldwide. PURPOSE To assess the prevalence of DED and potential associated risk factors in the Northern West Bank of Palestine. METHODS A cross sectional study was conducted in 16 selected towns in Northern West Bank governorates during December 2016 to September 2017. An interviewer-assisted Ocular Surface Disease Index (OSDI) questionnaire was used to study DED symptoms in the study population. Further evaluation of clinical signs of DED was performed using the following objective tests: tear film break-up time (TBUT), fluorescein corneal staining (FL/S) and Schirmer test. Subjects with an OSDI score of 13 or above were considered symptomatic of DED, and DED was defined if an OSDI score ≥ 13 is accompanied by at least one of the following signs in the worse eye: TBUT ≤10 s, Schirmer score ≤ 5 mm and fluorescein corneal staining ≥ grade 1. RESULTS Seven hundred sixty-nine subjects were recruited from the general non-clinical population in the West Bank. The mean age of participants was 43.61 ± 18.57 years ranging from 18 to 90 years. Females constitute 52.7% of the study population. Based on the diagnostic criteria, the prevalence of DED was 64% (95% confidence interval 60.6-67.3). DED was significantly associated with female gender p = (0.001) and older age p = (0.001). CONCLUSION The prevalence of DED is high in the study population. Older age and female gender were associated risk factors with the development of DED.

中文翻译:

巴勒斯坦西岸北部16个城镇的干眼病患病率和相关危险因素:一项横断面研究。

背景技术干眼病(DED)是睑间眼表面和泪膜的多因素疾病,其导致不适,疲劳和视力障碍。DED影响患者的生活质量,并最终导致生产力下降。而且,它具有相当大的社会经济负担。这是一个日益严重的未被充分诊断的健康问题,可能的相关风险因素非常普遍,并且在全球范围内持续增长。目的评估巴勒斯坦西北银行DED的患病率和潜在的相关危险因素。方法在2016年12月至2017年9月期间,在西岸北部省份的16个选定城镇中进行了一项横断面研究。采用访谈员辅助的眼表疾病指数(OSDI)问卷调查了研究人群中的DED症状。使用以下客观测试对DED的临床体征进行进一步评估:泪膜破裂时间(TBUT),荧光素角膜染色(FL / S)和Schirmer测试。OSDI得分为13或更高的受试者被认为是DED的症状,如果OSDI得分≥13并伴有以下至少一种不适症状,则定义DED:TBUT≤10 s,Schirmer得分≤5 mm结果:角膜荧光标记和荧光素≥1级。结果从西岸的普通非临床人群中招募了679名受试者。参与者的平均年龄为43.61±18.57岁,范围从18到90岁。女性占研究人口的52.7%。根据诊断标准,DED的患病率为64%(95%置信区间为60.6-67.3)。DED与女性性别p =(0.001)和较大年龄p =(0.001)显着相关。结论在研究人群中DED的患病率很高。高龄和女性是与DED发展相关的危险因素。
更新日期:2020-01-14
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