BACKGROUND We aim to synthesize the up-to-date studies to investigate the diagnostic value of serum soluble triggering expressed receptor on myeloid cells 1 (sTREM-1) in suspected sepsis. RESULTS A total of 19 studies with 2418 patients were finally enrolled in the meta-analysis. The pooled sensitivity was 0.82 (95% CI 0.73 to 0.89), specificity 0.81 (95% CI 0.75 to 0.86), positive likelihood ratio 4.3 (95% CI 3.02 to 6.12), negative likelihood ratio 0.22 (95% CI 0.24 to 0.35), diagnostic odds ratio 20 (95% CI 9 to 41) and AuROC 0.88 (95% CI 0.85 to 0.91). The meta-regression analysis revealed that the sample size, reference standard description, prevalence of sepsis in the trials and consecution of patient recruitment might be the source of heterogeneity. CONCLUSIONS The serum sTREM-1 had a moderate ability in diagnosis in suspected sepsis based on the current studies. However, more large-scale studies were needed to further evaluate the diagnostic accuracy of sTREM-1.

中文翻译：

---

疑似脓毒症中髓样细胞1（sTREM-1）的血清可溶性触发表达受体的诊断价值：一项荟萃分析。

背景技术我们旨在综合最新研究，以研究可疑脓毒症中髓样细胞1（sTREM-1）的血清可溶性触发表达受体的诊断价值。结果共有19项研究（2418例患者）最终纳入荟萃分析。合并敏感性为0.82（95％CI为0.73至0.89），特异性0.81（95％CI为0.75至0.86），正似然比为4.3（95％CI为3.02至6.12），负似然比为0.22（95％CI为0.24至0.35） ，诊断优势比20（95％CI 9至41）和AuROC 0.88（95％CI 0.85至0.91）。荟萃回归分析显示，样本量，参考标准说明，败血症在试验中的流行以及患者招募的进行可能是异质性的来源。结论根据目前的研究，血清sTREM-1对可疑脓毒症的诊断能力中等。但是，需要更多的大规模研究来进一步评估sTREM-1的诊断准确性。