Abstract Gold nanocatalyst was efficiently applied in the synthesis of 2–aryl–2,3–dihydroquinazolin–4(1H)–ones using very small catalyst amount (0.6 gold mol%). These heterocyclic compounds, which can be synthesized by direct condensation of aromatic aldehydes with 2–aminobenzamide, have been recognized as core structure for medicinal drug development. The success of the nanocatalyst lies on its characteristics that allow the formation of small gold nanoparticles strongly adhered to the surface of SBA–15 material, in a highly dispersed way. For this, SBA–15 was modified with a thin coating of cationic silsesquioxane. This coating allows the immobilization of AuCl4− complex by ion-exchange. The offered gold amount was lower than the cationic coating capacity, thus ensuring that the gold amount added was totally anchored and converted into small nanoparticles during the reduction process. The presence of gold nanoparticles did not affect drastically the textural characteristics of the SBA–15, ensuring the diffusion of reactants and ensuing access to the reactive catalyst sites.

中文翻译：

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多相金纳米催化剂在2-芳基-2,3-二氢喹唑啉-4(1H)-酮合成中的应用

摘要 金纳米催化剂可有效地用于合成 2-芳基-2,3-二氢喹唑啉-4(1H)-酮类，且催化剂用量极少（0.6 摩尔金）。这些杂环化合物可以通过芳香醛与 2-氨基苯甲酰胺直接缩合合成，已被公认为药物开发的核心结构。纳米催化剂的成功在于它的特性，它允许形成小的金纳米颗粒，以高度分散的方式牢固地粘附在 SBA-15 材料的表面。为此，SBA-15 用阳离子倍半硅氧烷的薄涂层进行了改性。该涂层允许通过离子交换固定 AuCl4- 复合物。提供的金量低于阳离子涂层容量，从而确保添加的金量在还原过程中完全锚定并转化为小纳米颗粒。金纳米粒子的存在不会显着影响 SBA-15 的质地特性，确保反应物的扩散并确保进入反应性催化剂位点。