The ectoparasite, Lepeophtheirus salmonis (Kroyer 1837), is effective at avoiding elimination from its host, Atlantic salmon, Salmo salar L., by inhibiting the recruitment of immune cells to the site of attachment. In other ectoparasitic arthropods, numerous factors have been identified that bind or neutralize chemokines preventing their interaction with receptors on the surfaces of immune cells. To determine if L. salmonis is utilizing a similar mechanism of immune modulation, the chemotactic activity of peripheral blood leukocytes (PBL) to leukotriene B4 (LTB4) and the secreted/excreted products (SEPs) of the sea louse were investigated in vitro. The results showed that incubation of LTB4 with SEPs reduced leukocyte migration compared to LTB4 immune stimulation alone. Data suggests that one of the mechanisms L. salmonis may be using to regulate immune cell recruitment in Atlantic salmon is by inhibiting or neutralizing the activity of chemokines.

中文翻译：

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鲑鱼麻风的分泌/排泄产物中的抗趋化活性。

体外寄生虫鲑鱼Lepeophtheirus（Kroyer 1837）通过抑制免疫细胞募集到附着位点，有效避免其宿主大西洋鲑Salmo salar L.的清除。在其他外寄生节肢动物中，已发现许多结合或中和趋化因子的因子，阻止其与免疫细胞表面受体的相互作用。为了确定鲑鱼沙门氏菌是否正在利用类似的免疫调节机制，在体外研究了外周血白细胞（PBL）对白三烯B4（LTB4）和海虱分泌/分泌产物（SEPs）的趋化活性。结果表明，与单独的LTB4免疫刺激相比，将LTB4与SEP一起孵育可减少白细胞迁移。数据表明机制之一是L。