Endometrial cancer is one of the most common gynaecological malignancies worldwide. One type of research in this field is the growing of cell lines (CLs) and cultures, which can be used to explore the biological mechanisms of cancer. The purpose of this review is to offer an overview of the current literature and highlight the importance of correct CL studies. We carried out a literature analysis of more than 60 articles from the Pubmed, Medline databases that were almost exclusively published in indexed journals in the last 10 years as well as the primary originating scientific studies of specific CLs. We then summarized the newest findings and recommendations. Cell lines are becoming widely used as in vitro tumour models. Recent work has shown inconsistencies in nomenclature and culturing of CLs. Their genomic evolution leads to a high degree of variation across CL strains therefore it is of the utmost importance to recognize the variability within laboratory cancer models. Laboratories must adapt, incorporate additional characterisation techniques and view this situation as an opportunity to improve the reproducibility of pre-clinical cancer research. The authors offer a comprehensive literature review about endometrial cancer CLs, a review of the current literature and advice on culturing CLs.

中文翻译：

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子宫内膜癌及其细胞系。

子宫内膜癌是全世界最常见的妇科恶性肿瘤之一。该领域的一种研究类型是细胞系（CLs）和培养物的生长，可用于探索癌症的生物学机制。这篇综述的目的是提供对当前文献的概述，并强调正确的CL研究的重要性。我们对来自Pubmed，Medline数据库的60多篇文章进行了文献分析，这些文章在过去10年中几乎全部以索引形式发表在期刊上，以及针对特定CL的主要原始科学研究。然后，我们总结了最新发现和建议。细胞系正被广泛用作体外肿瘤模型。最近的工作表明CL的命名和培养存在不一致之处。它们的基因组进化会导致CL菌株之间高度差异，因此，最重要的是要认识实验室癌症模型中的变异性。实验室必须适应，结合其他表征技术，并将这种情况视为提高临床前癌症研究可重复性的机会。作者提供了有关子宫内膜癌CL的综合文献综述，对当前文献的综述以及有关培养CL的建议。