A sensitive method based on the use of green deep eutectic solvents (DESs) was designed for the determination of bisphenol-A, bisphenol-AF, tetrabromobisphenol-A and 4-tert.-octylphenol followed by HPLC. This method takes advantage of magnetic solid-phase extraction purification and acid-base induced DES liquid-liquid microextraction. The Mg(II)-Al(III) layered double hydroxide-coated magnetic nanoparticles were selected to purify samples. The DESs were systematically prepared by a range of medium-chain saturated fatty acids (C 8 -C 12 ) and D,L-menthol. The melting point and the extraction efficiency of phenolic compounds were adjusted by changing the carbon chain length of fatty acid in suitable proportions. Acid-base induction significantly improves the extraction efficiency. The method has lower limits of detection ranging from 6 to 11 ng L −1 , good linearity (0.05–500 μg L −1 ) and high enrichment factors (86–91). The method was successfully applied for the determination of four phenolic compounds in beverage samples. The recoveries ranged from 84.4 to 101.3%. Graphical abstract Schematic representation of the extraction of four phenolic compounds by medium chain (C 8 -C 12 ) fatty acid-based eutectic solvent (DES) through acid-base-induction.

中文翻译：

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酸碱控制的深共晶溶剂微萃取结合磁固相萃取测定酚类化合物

设计了一种基于使用绿色低共熔溶剂 (DESs) 的灵敏方法，用于测定双酚 A、双酚 AF、四溴双酚 A 和 4-叔辛基苯酚，然后使用 HPLC。该方法利用了磁性固相萃取纯化和酸碱诱导的 DES 液-液微萃取。选择 Mg(II)-Al(III) 层状双氢氧化物涂层磁性纳米粒子来净化样品。DES 由一系列中链饱和脂肪酸 (C 8 -C 12 ) 和 D,L-薄荷醇系统制备。通过适当比例改变脂肪酸的碳链长度来调节酚类化合物的熔点和提取效率。酸碱诱导显着提高提取效率。该方法具有较低的检测限，范围为 6 至 11 ng L -1 ，线性良好（0.05-500 μg L -1 ）和高富集因子（86-91）。该方法已成功应用于饮料样品中四种酚类化合物的测定。回收率范围为 84.4% 至 101.3%。图形摘要 中链 (C 8 -C 12 ) 脂肪酸基共晶溶剂 (DES) 通过酸碱诱导提取四种酚类化合物的示意图。