Intratumoral genetic heterogeneity of driver somatic mutations is present in a variety of tumor types, yet the extent of heterogeneity is variable. We propose that this variation is a reflection of the inherent biology of a given tumor type, representing the pace of metastatic dissemination and hence clinical disease course.

中文翻译：

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瘤内异质性反映临床病程

驱动体细胞突变的瘤内遗传异质性存在于多种肿瘤类型中，但异质性的程度是可变的。我们认为这种变异反映了给定肿瘤类型的固有生物学特性，代表了转移传播的速度和临床病程。