The site-specific monoubiquitination of FANCD2 is crucial for the Fanconi anemia DNA repair pathway and tumor suppression. This modification is mediated by the E2 enzyme UBE2T and the E3 ligase FANCL through a novel allosteric mechanism.

中文翻译：

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重新接线E2酶。

FANCD2的位点特异性单泛素化对于Fanconi贫血DNA修复途径和肿瘤抑制至关重要。这种修饰是由E2酶UBE2T和E3连接酶FANCL通过新颖的变构机制介导的。