Integrins are heterodimeric transmembrane receptors that connect the extracellular matrix environment to the actin cytoskeleton via adaptor molecules through assembly of a range of adhesion structures. Recent advances in biochemical, imaging and biophysical methods have enabled a deeper understanding of integrin signalling and their associated regulatory processes. The identification of the consensus integrin-based 'adhesomes' within the last 5 years has defined common core components of adhesion complexes and associated partners. These approaches have also uncovered unexpected adhesion protein behaviour and molecules recruited to adhesion sites that have expanded our understanding of the molecular and physical control of integrin signalling.

中文翻译：

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整合素依赖性粘连的新视角。

整合素是异二聚体跨膜受体，通过一系列粘附结构的组装，通过衔接分子将细胞外基质环境与肌动蛋白细胞骨架连接起来。生物化学、成像和生物物理方法的最新进展使人们能够更深入地了解整合素信号传导及其相关的调控过程。过去五年内基于整合素的共识“粘附体”的鉴定已经定义了粘附复合物和相关伙伴的共同核心成分。这些方法还揭示了意想不到的粘附蛋白行为和招募到粘附位点的分子，扩大了我们对整合素信号传导的分子和物理控制的理解。