In this work, a sol-gel technique was applied to synthesize mesoporous silica (MPS_S) SBA-15 and modify it to magnetic mesoporous (MMP_S) Fe₃O₄/SBA-15. The surface engineering modification was implemented according to the incipient wetness impregnation (IWI) method to create specific magnetic sites adsorbent for loading and release of Meloxicam (MEL). The MPS_S and MMP_S were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), Fourier transform infrared (FT-IR), BET surface area, and thermal gravimetric analysis (TGA). Four parameters were investigated: pH, concentration of drug, dose of carriers, and contact time. The maximum drug loading efficiencies (DL%) on SBA-15 and Fe₃O₄/SBA-15were 31.81 % and 42.85 % respectively. The MEL released was studied in phosphate buffer solution (PBS) at pH 7.4. The release of MEL from SBA-15 and Fe₃O₄/SBA-15 after 18 and 24 h was 85.76 % and 78.13 % respectively. Freundlich adsorption isotherm was the most acceptable for the two carrier’s SBA-15 and Fe₃O₄/SBA-15. The kinetics models for the drugs release fitted well with the first order kinetic model. The drug loading process was investigated in a batch system by implementation of experimental design technique. The objective function (response) was the drug loading efficiency (DL%). A response surface method (RSM) was applied to define the optimum and significant factors that affect the drug loading process.

在这项工作中，采用溶胶-凝胶技术合成介孔二氧化硅（MPS _S）SBA-15，并将其改性为磁性介孔（MMP _S）Fe ₃ O ₄ / SBA-15。根据初期润湿浸渍（IWI）方法进行了表面工程改造，以创建用于加载和释放美洛昔康（MEL）的特定磁性部位吸附剂。MPS _S和MMP _S通过X射线衍射（XRD），扫描电子显微镜（SEM），傅立叶变换红外（FT-IR），BET表面积和热重分析（TGA）对其进行表征。研究了四个参数：pH，药物浓度，载体剂量和接触时间。SBA-15和Fe ₃ O ₄ / SBA- 15的最大载药效率（DL％）分别为31.81％和42.85％。在pH 7.4的磷酸盐缓冲溶液（PBS）中研究了释放的MEL。18和24小时后，SBA-15和Fe ₃ O ₄ / SBA-15中的MEL释放量分别为85.76％和78.13％。Freundlich吸附等温线是两种载体的SBA-15和Fe ₃ O ₄最可接受的/ SBA-15。药物释放的动力学模型与一级动力学模型非常吻合。通过实施实验设计技术，在批处理系统中研究了药物装载过程。目标函数（响应）是载药效率（DL％）。应用响应面法（RSM）定义影响药物加载过程的最佳因素和重要因素。