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A powerful combination of copper-cysteamine nanoparticles with potassium iodide for bacterial destruction
Biomaterials Advances ( IF 7.9 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.msec.2020.110659
Xiumei Zhen , Lalit Chudal , Nil Kanatha Pandey , Jonathan Phan , Xin Ran , Eric Amador , Xuejing Huang , Omar Johnson , Yuping Ran , Wei Chen , Michael R. Hamblin , Liyi Huang

Herein, for the first time, we demonstrate that the combination of copper-cysteamine (Cu-Cy) nanoparticles (NPs) and potassium iodide (KI) can significantly inactivate both Gram-positive MRSA and Gram-negative E. coli. To uncover the mystery of the killing, the interaction of KI with Cu-Cy NPs was investigated systematically and the products from their interaction were identified. No copper ions were released after adding KI to Cu-Cy NPs in cell-free medium and, therefore, it is reasonable to conclude that the Fenton reaction induced by copper ions is not responsible for the bacterial killing. Based on the observations, we propose that the major killing mechanism involves the generation of toxic species, such as hydrogen peroxide, triiodide ions, iodide ions, singlet oxygen, and iodine molecules. Overall, the powerful combination of Cu-Cy NPs and KI has good potential as an independent treatment or a complementary antibiotic treatment to infectious diseases.



中文翻译:

铜-半胱胺纳米颗粒与碘化钾的强力组合,可杀死细菌

在这里,我们首次证明,铜-半胱胺(Cu-Cy)纳米颗粒(NPs)和碘化钾(KI)的组合可以显着灭活革兰氏阳性MRSA和革兰氏阴性大肠杆菌。为了揭示杀戮的奥秘,系统地研究了KI与Cu-Cy NP的相互作用,并鉴定了其相互作用的产物。在无细胞培养基中将KI加入Cu-Cy NP后,没有释放铜离子,因此可以合理地得出结论,铜离子诱导的Fenton反应与细菌杀灭无关。根据观察结果,我们认为主要的杀灭机制涉及有毒物质的产生,例如过氧化氢,三碘离子,碘离子,单线态氧和碘分子。总体而言,Cu-Cy NP和KI的强大组合具有作为独立治疗或补充性抗生素治疗传染病的良好潜力。

更新日期:2020-01-11
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