Metabolic reprogramming in macrophages supports effector functions and differs depending on the activating stimulus. Lauterbach et al. now show that early metabolic alterations in macrophages driven by LPS signaling serve to increase the acetyl-CoA pool via citrate metabolism by the ATP-citrate lyase (ACLY), leading to histone acetylation and regulation of TLR-driven gene expression.

中文翻译：

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在免疫代谢重编程过程中将巨噬细胞ACLY交配成组蛋白修饰。

巨噬细胞中的代谢重编程支持效应子功能，并根据激活刺激而有所不同。劳特巴赫等。现在显示，LPS信号驱动的巨噬细胞早期代谢改变可通过ATP柠檬酸裂解酶（ACLY）通过柠檬酸代谢增加乙酰辅酶A库，从而导致组蛋白乙酰化和TLR驱动基因表达的调节。