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The Peril and Promise of Integrons: Beyond Antibiotic Resistance.
Trends in Microbiology ( IF 15.9 ) Pub Date : 2020-01-13 , DOI: 10.1016/j.tim.2019.12.002
Timothy M Ghaly 1 , Jemma L Geoghegan 1 , Sasha G Tetu 2 , Michael R Gillings 3
Affiliation  

Integrons are bacterial genetic elements that can capture, rearrange, and express mobile gene cassettes. They are best known for their role in disseminating antibiotic-resistance genes among pathogens. Their ability to rapidly spread resistance phenotypes makes it important to consider what other integron-mediated traits might impact human health in the future, such as increased virulence, pathogenicity, or resistance to novel antimicrobial strategies. Exploring the functional diversity of cassettes and understanding their de novo creation will allow better pre-emptive management of bacterial growth, while also facilitating development of technologies that could harness integron activity. If we can control integrons and cassette formation, we could use integrons as a platform for enzyme discovery and to construct novel biochemical pathways, with applications in bioremediation or biosynthesis of industrial and therapeutic molecules. Integron activity thus holds both peril and promise for humans.

中文翻译:

整合素的危害和前景:超越抗生素耐药性。

整合素是细菌的遗传元件,可以捕获,重排和表达可移动的基因盒。它们以在病原体中传播抗生素抗性基因的作用而闻名。它们迅速传播抗性表型的能力使得考虑其他整合子介导的性状将来可能会影响人类健康的因素变得很重要,例如增加的毒力,致病性或对新型抗菌策略的抵抗力。探索盒的功能多样性并了解它们的从头创造,将可以更好地先发性地控制细菌的生长,同时也促进可利用整合子活性的技术的发展。如果我们可以控制整合素和盒形成,我们可以将整合素用作酶发现和构建新的生化途径的平台,在工业和治疗分子的生物修复或生物合成中的应用。因此,整合子的活动对人类既危险又充满希望。
更新日期:2020-01-13
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