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Metal-catalyzed C–H bond functionalization of phenol derivatives
Tetrahedron ( IF 2.1 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.tet.2020.130925
Hamad H. Al Mamari , Bogdan Štefane , Helena Brodnik Žugelj

Phenols and phenol derivatives constitute important starting materials, synthetic intermediates, and functional moieties of a broad range of chemicals and materials. They represent large production products of benzene and benzene derivative oxidation and are nowadays progressively available from biomass sources. In last decades or so, there have been tremendous advances in the field of catalytic C–H bond functionalization, among which metal-catalyzed C–H bond functionalization of phenol derivatives plays a substantial role. In this review, the latest transition metal catalyzed C–H bond functionalizations of phenol derivatives are summarized. These methods are powerful tools for the arylation, alkenylation, and acylation as well as annulation of phenol derivatives, especially as they can be carried out in a highly step-economical manner with readily available starting materials based on simple aryl (pseudo)halides, alkenes as reagents. Additionally, this review summarizes the main mechanistic aspects of the covered topic.



中文翻译:

金属催化的苯酚衍生物的CH键的官能化

苯酚和苯酚衍生物构成重要的原料,合成中间体以及各种化学物质和材料的功能部分。它们代表了苯和苯衍生物氧化的大型生产产品,如今可从生物质来源逐步获得。在过去的几十年左右的时间里,在催化C–H键功能化领域取得了巨大的进步,其中金属催化的苯酚衍生物的C–H键功能化发挥了重要作用。在这篇综述中,总结了最新的过渡金属催化的苯酚衍生物的CH键的官能化。这些方法是进行芳基化,烯基化和酰化以及苯酚衍生物环合的强大工具,特别是因为它们可以高度经济地使用基于简单的芳基(假)卤化物,烯烃作为试剂的起始原料来进行。此外,本评论总结了所涵盖主题的主要机械方面。

更新日期:2020-01-13
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