An efficient approach for the direct aminomethylation of imidazo[1,2–a]pyridine with 3-dimethylaminopropionitrile has been realized at room temperature. This methodology has several advantages: (1) using efficient manganese (III) and inexpensive K₂S₂O₈ as oxidants, (2) mild reaction conditions, (3) good functional group tolerance for 26 examples. An array of aminomethylated imidazopyridines broad functionalities were obtained in good to excellent yields.

中文翻译：

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TEMPO介导的咪唑并吡啶交叉脱氢偶联氨甲基化

在室温下，已经实现了使用3-二甲基氨基丙腈直接使咪唑并[1,2-a]吡啶进行氨基甲基化的有效方法。该方法具有几个优点：（1）使用有效的锰（III）和廉价的K ₂ S ₂ O ₈作为氧化剂；（2）温和的反应条件；（3）26个实例的良好的官能团耐受性。以良好至优异的产率获得了一系列氨基甲基化的咪唑并吡啶具有广泛的功能。