Combined administration of different drugs is a widely acknowledged approach for effective cancer therapy. However, the limited targeting, as well as inferior drug loading capacities of current drug delivery systems (DDS), are still the bottleneck for better performance in cancer treatment. Herein, we successfully developed a cancer cell membrane (CM) decorated calcium carbonate (CC) hybrid nanoparticles (HN) for the co-delivery of cisplatin (CDDP) and oleanolic acid (OA). The physicochemical property of HN/CDDP/OA was evaluated, which revealed that the as-prepared DDS was core-shell structured and well-dispersed nanoparticles with size around 100 nm. The HN/CDDP/OA showed high stability and biocompatibility with pH-responsive drug release. Moreover, the CM modification in HN also demonstrated highly elevated tumor-homing nature than bare CC. Finally, the feasibility of HN/CDDP/OA in the treatment of gastric cancer (MGC-803 cell line) was assessed. HN/CDDP/OA showed better performance than mono systems with enhanced apoptosis and capable of reversing multidrug resistance (MDR) of cancer cells.

中文翻译：

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顺铂-齐墩果酸共负载杂化纳米颗粒对胃癌细胞的协同作用增强细胞凋亡和逆转多药耐药性。

不同药物的联合给药是一种广泛认可的有效癌症治疗方法。然而，目前药物递送系统（DDS）的靶向性有限以及药物负载能力较差，仍然是癌症治疗更好性能的瓶颈。在此，我们成功开发了一种癌细胞膜 (CM) 修饰的碳酸钙 (CC) 杂化纳米粒子 (HN)，用于顺铂 (CDDP) 和齐墩果酸 (OA) 的共同递送。对 HN/CDDP/OA 的物理化学性质进行了评价，结果表明，所制备的 DDS 是核壳结构且分散良好的纳米粒子，尺寸约为 100 nm。HN/CDDP/OA 表现出高稳定性和生物相容性，具有 pH 响应性药物释放。此外，HN 中的 CM 修饰也表现出比裸 CC 更高的肿瘤归巢性质。最后，评估了HN/CDDP/OA治疗胃癌（MGC-803细胞系）的可行性。HN/CDDP/OA 表现出比单一系统更好的性能，具有增强的细胞凋亡并能够逆转癌细胞的多药耐药性 (MDR)。