African Mitochondrial DNA Haplogroup L2 is Associated with Slower Decline of β-Cell Function and Lower Incidence of Diabetes Mellitus in non-Hispanic Black Women with HIV.,Clinical Infectious Diseases

当前位置： X-MOL 学术 › Clin. Infect. Dis. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

African Mitochondrial DNA Haplogroup L2 is Associated with Slower Decline of β-Cell Function and Lower Incidence of Diabetes Mellitus in non-Hispanic Black Women with HIV.
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2020-01-12 , DOI: 10.1093/cid/ciaa026
Jing Sun ₁ , Todd T Brown _{1,

2} , Weiqun Tong ₁ , David Samuels ₃ , Phyllis Tien _{4,

5} , Brahim Aissani ₆ , Bradley Aouizerat ₇ , Maria Villacres ₈ , Mark H Kuniholm ₉ , Deborah Gustafson ₁₀ , Katherine Michel ₁₁ , Mardge Cohen ₁₂ , Michael Schneider ₁ , Adaora A Adimora ₁₃ , Mohammed K Ali ₁₄ , Hector Bolivar ₁₅ , Todd Hulgan _{16,

17}

Affiliation

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Department of Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Department of Medicine, Division of Infectious Disease, University of California-San Francisco, San Francisco, CA, USA.
Department of Veterans Affairs Medical Center, San Francisco, San Francisco, CA, USA.
Department of Epidemiology, University of Alabama-Birmingham, Birmingham, Alabama, USA.
Rory Meyers College of Nursing, New York University, New York, New York, USA.
Department of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, USA.
Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
Department of Medicine, Georgetown University, Washington, DC, USA.
Hektoen Institute for Medical Research, Chicago, Illinois, USA.
School of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Department of Epidemiology, Emory University, Atlanta, Georgia, USA.
Miller School of Medicine, Infectious Diseases Division, University of Miami, Miami, Florida, USA.
Tennessee Valley Healthcare System-Veterans Affairs Hospital, Nashville, Tennessee, USA.
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Susceptibility to metabolic diseases may be influenced by mitochondrial genetic variability among people living with human immunodeficiency virus (HIV; PLWH), but remains unexplored in populations with African ancestry. We investigated the association between mitochondrial DNA (mtDNA) haplogroups and the homeostatic model assessments of β-cell function (HOMA-B) and insulin resistance (HOMA-IR), as well as incident diabetes mellitus (DM), among Black women living with or at risk for HIV.

中文翻译：

非洲线粒体 DNA 单倍群 L2 与感染 HIV 的非西班牙裔黑人女性的 β 细胞功能衰退较慢和糖尿病发病率较低有关。

对代谢疾病的易感性可能受到人类免疫缺陷病毒 (HIV; PLWH) 感染者线粒体遗传变异性的影响，但在非洲血统人群中仍未得到探索。我们调查了线粒体 DNA (mtDNA) 单倍群与 β 细胞功能 (HOMA-B) 和胰岛素抵抗 (HOMA-IR) 的稳态模型评估之间的关联，以及在患有糖尿病的黑人女性中发生的糖尿病 (DM)。或有感染艾滋病毒的风险。

更新日期：2020-01-12

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>