Long‐term cognitive decline is an adverse outcome after major surgery associated with increased risk for mortality and morbidity. We studied the cerebrospinal fluid (CSF) and serum biochemical inflammatory response to a standardized orthopedic surgical procedure and the possible association with long‐term changes in cognitive function. We hypothesized that the CSF inflammatory response pattern after surgery would differ in patients having long‐term cognitive decline defined as a composite cognitive z score of ≥1.0 compared to patients without long‐term cognitive decline at 3 months postsurgery.

中文翻译：

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神经炎症标志物与大手术后认知能力下降有关：一项探索性研究的结果

长期认知能力下降是大手术后的不良结果，与死亡率和发病率的风险增加有关。我们研究了标准化骨科手术的脑脊液 (CSF) 和血清生化炎症反应，以及与认知功能长期变化的可能关联。我们假设，与术后 3 个月没有长期认知下降的患者相比，长期认知下降定义为复合认知 z 评分≥1.0 的患者在手术后的脑脊液炎症反应模式会有所不同。