There are currently no definitive disease‐modifying therapies for traumatic brain injury (TBI). In this study, we present a strong therapeutic candidate for TBI, immunomodulatory nanoparticles (IMPs), which ablate a specific subset of hematogenous monocytes (hMos). We hypothesized that prevention of infiltration of these cells into brain acutely after TBI would attenuate secondary damage and preserve anatomic and neurologic function.

中文翻译：

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静脉注射免疫调节纳米粒子治疗创伤性脑损伤

目前尚无针对创伤性脑损伤 (TBI) 的明确疾病缓解疗法。在这项研究中，我们提出了一种强大的 TBI 治疗候选药物，即免疫调节纳米颗粒 (IMP)，它可以消融特定的血源性单核细胞 (hMos) 子集。我们假设，在 TBI 后防止这些细胞急剧渗入大脑将减轻继发性损伤并保留解剖和神经功能。