Supplemental Digital Content is available in the text. Limited data exist evaluating the effect of blood pressure (BP) on clinical outcomes among patients with acute ischemic stroke with large vessel occlusion treated with mechanical thrombectomy (MT). We sought to evaluate the association of BP levels on clinical outcomes among patients with acute ischemic stroke with large vessel occlusion treated with MT. Studies were identified that reported the association of systolic BP (SBP) or diastolic BP levels before, during, or after MT on the outcomes of patients with acute ischemic stroke treated with MT. Unadjusted and adjusted analyses of studies reporting odds ratios (ORadj) per 10 mm Hg BP increment were performed. Our analysis included 25 studies comprising 6474 patients. Higher pre-MT mean SBP (P=0.008) and post-MT maximum SBP (P=0.009) levels were observed in patients who died within 3 months. Patients with 3-month functional independence were noted to have lower pre-MT (P<0.001) and post-MT maximum SBP levels (P<0.001). In adjusted analyses, increasing post-MT maximum SBP and diastolic BP levels were associated with 3-month mortality (ORadj, 1.19 [95% CI,1.00–1.43]; I2=78%, P value for Cochran Q test: 0.001) and symptomatic intracranial hemorrhage (ORadj, 1.65 [95% CI, 1.11–2.44]; I2=0%, P value for Cochran Q test: 0.80), respectively. Increasing pre- and post-MT mean SBP levels were associated with lower odds of 3-month functional independence (ORadj, 0.86 [95% CI, 0.77–0.96]; I2=18%, P value for Cochran Q test: 0.30) and (ORadj, 0.80 [95% CI, 0.72–0.89]; I2=0%, P value for Cochran Q test: 0.51), respectively. In conclusion, elevated BP levels before and after MT are associated with adverse outcomes among patients with acute ischemic stroke with large vessel occlusion.

中文翻译：

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血压与急性卒中血栓切除术结果的相关性

补充数字内容在文本中可用。评估血压 (BP) 对机械取栓 (MT) 治疗的大血管闭塞急性缺血性卒中患者临床结果影响的数据有限。我们试图在接受 MT 治疗的伴有大血管闭塞的急性缺血性卒中患者中评估血压水平与临床结果的相关性。确定的研究报告了 MT 之前、期间或之后的收缩压 (SBP) 或舒张压水平与 MT 治疗的急性缺血性卒中患者的结果之间的关联。对报告每 10 mmHg BP 增量的优势比 (ORadj) 的研究进行了未经调整和调整的分析。我们的分析包括 25 项研究，包括 6474 名患者。更高的 MT 前平均 SBP (P=0.008) 和 MT 后最大 SBP (P=0. 009) 水平在 3 个月内死亡的患者中观察到。注意到功能独立 3 个月的患者具有较低的 MT 前 (P<0.001) 和 MT 后最大 SBP 水平 (P<0.001)。在调整后的分析中，MT 后最大 SBP 和舒张压水平升高与 3 个月死亡率相关（ORadj，1.19 [95% CI，1.00–1.43]；I2=78%，Cochran Q 检验的 P 值：0.001）和症状性颅内出血（ORadj，1.65 [95% CI，1.11–2.44]；I2=0%，Cochran Q 检验的 P 值：0.80）。MT 前后平均 SBP 水平的增加与 3 个月功能独立的几率降低相关（ORadj，0.86 [95% CI，0.77–0.96]；I2=18%，Cochran Q 检验的 P 值：0.30）和（ORadj，0.80 [95% CI，0.72–0.89]；I2=0%，Cochran Q 检验的 P 值：0.51）。综上所述，