Active sleep (AS) provides a unique developmental context for synchronizing neural activity within and between cortical and subcortical structures. In week-old rats, sensory feedback from myoclonic twitches, the phasic motor activity that characterizes AS, promotes coherent theta oscillations (4-8 Hz) in the hippocampus and red nucleus, a midbrain motor structure. Sensory feedback from twitches also triggers rhythmic activity in sensorimotor cortex in the form of spindle bursts, which are brief oscillatory events composed of rhythmic components in the theta, alpha/beta (8-20 Hz), and beta2 (20-30 Hz) bands. Here we ask whether one or more of these spindle-burst components are communicated from sensorimotor cortex to hippocampus. By recording simultaneously from whisker barrel cortex and dorsal hippocampus in 8-day-old rats, we show that AS, but not other behavioral states, promotes cortico-hippocampal coherence specifically in the beta2 band. By cutting the infraorbital nerve to prevent the conveyance of sensory feedback from whisker twitches, cortical-hippocampal beta2 coherence during AS was substantially reduced. These results demonstrate the necessity of sensory input, particularly during AS, for coordinating rhythmic activity between these two developing forebrain structures.

中文翻译：

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主动睡眠促进幼鼠皮质-海马系统的相干振荡活动。

主动睡眠 (AS) 为同步皮层和皮层下结构内部和之间的神经活动提供了独特的发育环境。在一周大的大鼠中，来自肌阵挛抽搐（AS 的特征性运动活动）的感觉反馈促进了海马和红核（一种中脑运动结构）中的连贯 theta 振荡（4-8 Hz）。来自抽搐的感觉反馈也以纺锤波爆发的形式触发感觉运动皮层的节律活动，这是由 theta、alpha/beta (8-20 Hz) 和 beta2 (20-30 Hz) 波段的节律成分组成的短暂振荡事件. 在这里，我们询问这些纺锤波爆发组件中的一个或多个是否从感觉运动皮层传递到海马体。通过同时记录 8 日龄大鼠的须桶皮层和背海马体，我们发现 AS、但不是其他行为状态，特别是在 beta2 带中促进皮质 - 海马的一致性。通过切断眶下神经以防止来自胡须抽搐的感觉反馈的传递，AS 期间皮质-海马 beta2 的一致性大大降低。这些结果证明了感觉输入的必要性，特别是在 AS 期间，用于协调这两个发育中的前脑结构之间的节律活动。