A new class of organosilicon-based radiosynthons, heteroaromatic silicon-fluoride acceptors, namely, HetSiFAs, that readily undergo isotope exchange with dry [18F]fluoride at room temperature in high radiochemical yield (up to 94%) with good molar activity is reported. Radiofluorination proceeds in a single step in 2 min without high-performance liquid chromatography purification to provide an operationally simple method for 18F-PET tracer production. This method was used to prepare an 18F-labeled commercial tetrapeptide, and positron emission tomography imaging confirmed in vivo stability.

中文翻译：

---

通过杂芳族氟化硅受体快速一步一步进行18F肽标记。

据报道，一类新型的有机硅基放射性合成子，即杂芳族氟化硅受体，即HetSiFAs，在室温下易于与干燥的[18F]氟化物进行同位素交换，且放射化学收率高（高达94％），具有良好的摩尔活性。放射性氟化仅需2分钟即可一步完成，而无需进行高效液相色谱纯化，从而为生产18F-PET示踪剂提供了一种操作简单的方法。该方法用于制备18 F标记的市售四肽，正电子发射断层显像证实其体内稳定性。