Macrocyclic structures are challenging synthetic targets owing to various potential applications ranging from drug discovery to nanomaterials. Their use, however, is highly limited due to synthetic difficulties arising from entropic penalty for folding of linear chains. Here we report single-layered porous nanosheets with 2-D ordered internal cavities that act as a highly efficient macrocycle generator, changing linear substrates to release as macrocycles in aqueous methanol solution. The nanosheets with hydrophobic cavities encapsulate a linear substrate with nearly perfect uptake, perform clean cyclization and then spontaneously release as a pure macrocycle. The self-separation of the macrocycle that precipitates from the solution leads to repeated cycles of macrocycle generation, thereby the single-layered porous materials enabling catch and release offer a powerful novel strategy for repeated macrocycle generation.

中文翻译：

---

用于大环化和自释放的多孔纳米片组装

由于从药物发现到纳米材料的各种潜在应用，大环结构是具有挑战性的合成目标。然而，由于线性链折叠的熵惩罚引起的合成困难，它们的使用受到很大限制。在这里，我们报告了具有二维有序内腔的单层多孔纳米片，它们充当高效的大环发生器，改变线性底物以在甲醇水溶液中作为大环释放。具有疏水腔的纳米片以几乎完美的吸收包裹线性基底，进行清洁环化，然后作为纯大环自发释放。从溶液中沉淀出来的大环的自分离导致大环生成的重复循环，