According to WHO World Malaria Report (2018), nearly 219 million new cases of malaria occurred and a total no. of 435 000 people died in 2017 due to this infectious disease. This is due to the rapid spread of parasite‐resistant strains. Artemisinin (ART), a sesquiterpene lactone endoperoxide isolated from traditional Chinese herb Artemisia annua, has been recognized as a novel class of antimalarial drugs. The 2015 “Nobel Prize in Physiology or Medicine” was given to Prof Dr Tu Youyou for the discovery of ART. Hence, ART is termed as “Nobel medicine.” The present review article accommodates insights from the chronological advancements and direct statistics witnessed during the past 48 years (1971‐2019) in the medicinal chemistry of ART‐derived antimalarial endoperoxides, and their clinical utility in malaria chemotherapy and drug discovery.

中文翻译：

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从工作台到床边的青蒿素衍生的抗疟内过氧化物：按时间顺序排列的进步和未来的挑战。

根据世卫组织世界疟疾报告（2018 年），近 2.19 亿疟疾新病例发生，总数为 2017 年有 43.5 万人死于这种传染病。这是由于抗寄生虫菌株的迅速传播。青蒿素 (ART)，一种从传统中草药青蒿中分离的倍半萜内酯内过氧化物，已被公认为一类新型抗疟药。2015 年“诺贝尔生理学或医学奖”授予屠呦呦教授，以表彰他发现了 ART。因此，ART被称为“诺贝尔医学”。本综述文章涵盖了过去 48 年（1971 年至 2019 年）在 ART 衍生的抗疟内过氧化物药物化学方面的时间顺序进步和直接统计数据，以及它们在疟疾化疗和药物发现中的临床效用。