BACKGROUND Pazopanib is a multitarget tyrosine kinase inhibitor used in the treatment of renal cancer and soft tissue sarcoma. Its use is commonly associated with a number of side effects, such as hemorrhagic diathesis, neutropenia, leukopenia, thrombocytopenia, nausea, vomiting, abdominal pain, increased serum aspartate aminotransferase, increased serum alanine aminotransferase, decreased serum glucose, increased serum bilirubin, decreased serum phosphate and magnesium, fatigue, hypertension, diarrhea, anorexia, proteinuria, and hypothyroidism. Abscesses of metastases caused by pazopanib administration are rarely reported in the literature. CASE PRESENTATION We report a case of abscesses of lung metastases related to pazopanib in a patient with metastatic renal cancer. The patient was a 53-year-old Caucasian man who developed abscesses of lung metastases during the first 3 months of treatment with pazopanib. The abscesses resolved after 1 month by stopping pazopanib and administering adequate antibiotic therapy. CONCLUSIONS We conclude that abscesses of metastases could be a rare side effect occurring during treatment with pazopanib in patients with renal cancer.

中文翻译：

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帕唑帕尼治疗转移性肾癌中脓肿的发生：一例报告。

背景技术帕唑帕尼是一种用于治疗肾癌和软组织肉瘤的多靶酪氨酸激酶抑制剂。它的使用通常与许多副作用相关，例如出血性素质，中性粒细胞减少症，白细胞减少症，血小板减少症，恶心，呕吐，腹痛，血清天冬氨酸转氨酶增加，血清丙氨酸氨基转移酶，血清葡萄糖减少，血清胆红素增加，血清减少磷酸盐和镁，疲劳，高血压，腹泻，厌食，蛋白尿和甲状腺功能低下。文献中很少报道由帕唑帕尼给药引起的转移灶脓肿。病例介绍我们报告了转移性肾癌患者中与帕唑帕尼有关的肺转移脓肿病例。该患者是一名53岁的白人男子，在帕唑帕尼治疗的前3个月内出现了肺转移脓肿。1个月后，停止帕唑帕尼并给予适当的抗生素治疗，脓肿得以缓解。结论我们得出结论，在帕唑帕尼治疗肾癌患者中，脓肿转移可能是罕见的副作用。