BACKGROUND Interleukin-10 (IL10) signalling pathway deficiency results in severe very early onset inflammatory bowel disease (VEOIBD), and enterostomy is often inevitable. However, studies in these surgical populations are lacking. This study aims to determine the enterostomy characteristics, postoperative complications and related risk factors in enterostomy patients. METHODS From March 1, 2015, to December 31, 2018, patients with IL10R-mutation who underwent enterostomy were recruited for analysis. We collected data on the patients' clinical characteristics, enterostomy characteristics, postoperative complications and related risk factors. RESULTS Twelve patients required emergency enterostomy, and 10 patients underwent elective enterostomy. Twelve patients experienced postoperative complications, including wound infection (27.3%), wound dehiscence (18.2%), reoperation (18.2%), etc. Compared with the pre-enterostomy values, there was a decrease in C-reactive protein (CRP) (P = 0.001), an increase in albumin (P = 0.001) and an improvement in the weight-for-age (P = 0.029) and body mass index (BMI) Z-scores (P = 0.004) after enterostomy. There was a significant difference between the pre-operation and postoperation medicine expenses (P = 0.002). Univariate binary logistic regression analysis revealed a statistically significant influence of CRP (OR: 1.43, 95% CI: 1.07-1.91, P = 0.016) and a tendency towards a significant influence of intestinal perforation, albumin level, BMI Z-score and weighted paediatric Crohn's disease activity index (wPCDAI). Multivariate logistic regression analysis showed that CRP (OR: 1.40), wPCDAI (OR: 2.88) and perforation (OR: 1.72) showed a tendency to behave as independent risk factors for postoperative complications, but the results were not significant (all P > 0.05). CONCLUSIONS Surgery and enterostomy showed benefits for VEOIBD with IL-10 signalling deficiency. The timing of intervention, potential postoperative complications, economic burden and other related problems should be considered.

中文翻译：

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肠造口的并发症以及非常早期发作的白细胞介素10信号缺乏的炎性肠病的相关危险因素分析：单中心回顾性分析。

背景技术白介素10（IL10）信号通路缺乏会导致严重的非常早期发作的炎症性肠病（VEOIBD），而肠造口术通常是不可避免的。然而，缺乏在这些外科手术人群中的研究。本研究旨在确定肠造口术患者的肠造口术特征，术后并发症和相关危险因素。方法自2015年3月1日至2018年12月31日，对接受肠造口术的IL10R突变患者进行分析。我们收集了有关患者的临床特征，肠造口术特征，术后并发症和相关危险因素的数据。结果12例患者需要紧急肠造口术，10例患者进行了选择性肠造口术。12名患者发生了术后并发症，包括伤口感染（占27.3％），伤口开裂（18.2％），再次手术（18.2％）等。与肠造口前值相比，C反应蛋白（CRP）减少（P = 0.001），白蛋白增加（P = 0.001）肠造口术后的年龄重（P = 0.029）和体重指数（BMI）Z评分（P = 0.004）有所改善。术前和术后药物费用之间存在显着差异（P = 0.002）。单变量二项logistic回归分析显示CRP具有统计学显着影响（OR：1.43，95％CI：1.07-1.91，P = 0.016），并且对肠穿孔，白蛋白水平，BMI Z评分和加权儿科有显着影响克罗恩病活动指数（wPCDAI）。多元logistic回归分析显示CRP（OR：1.40），wPCDAI（OR：2.88）和穿孔（OR：1。72）表现出倾向于作为术后并发症的独立危险因素的趋势，但结果并不显着（所有P> 0.05）。结论外科手术和肠造口术对具有IL-10信号缺乏的VEOIBD有益。应考虑干预的时间，潜在的术后并发症，经济负担和其他相关问题。