Nanomaterials have revolutionized many scientific fields and are widely applied to address environmental problems and to develop novel health care strategies. However, their mechanism of action is still poorly understood. Several nanomaterials for medical applications are based on quantum dots (QDs). Despite their amazing physico-chemical properties, quantum dots display significant adverse effects. In the present study, the effects of QDs on the motor nervous system of nematodes Caenorhabditis elegans have been investigated as a non-mammalian alternative model. We also explored the possibility of modifying the toxicity of QDs by coating with a cell-penetrating peptide gH625 and thus we analysed the effects determined by QDs-gH625 complexes on the nematodes. With this work, we have demonstrated, by in vivo experiments, that the peptide gH625 is able to reduce the side effects of metallic nanoparticle making them more suitable for medical applications.

中文翻译：

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用gH625功能化的量子点减弱了秀丽隐杆线虫的QDs氧化应激和致死性：一个模型系统。

纳米材料已经彻底改变了许多科学领域，并被广泛应用于解决环境问题和开发新颖的保健策略。但是，它们的作用机理仍知之甚少。几种用于医学应用的纳米材料都基于量子点（QD）。尽管其惊人的物理化学性质，量子点仍显示出明显的不利影响。在本研究中，作为非哺乳动物替代模型，已经研究了量子点对线虫秀丽隐杆线虫的运动神经系统的影响。我们还探索了通过涂有穿透细胞的肽gH625修饰QDs毒性的可能性，因此我们分析了QDs-gH625复合物对线虫的影响。通过这项工作，我们通过体内实验证明了