Obesity is a complex, chronic disease that arises according to the interaction between genetic and environmental factors. The expansion and growth of white adipose tissue (WAT) could be related to angiogenesis. Resveratrol and adrenomedullin (AdM) were used for the inhibition of angiogenesis in metabolically passive WAT for inhibiting the expansion of this tissue, and the activation of angiogenesis in metabolically active brown adipose tissue (BAT) for increasing daily energy consumption as a way of reducing obesity. Rats were divided into eight groups. Four obese groups were fed with a high-fat diet containing 60% fat as energy for three months. After obtaining obesity, 2.5 nmol/kg AdM and 10 mg/kg resveratrol were treated to experiment groups intraperitoneally (i.p.) every other day for four weeks. AdM and vascular endothelial growth factor A (VEGF-A) mRNA levels were detected with semi-quantitative PCR; protein levels were detected with Western Blotting. AdM and resveratrol are multifactorial molecules, thus, this study has revealed a few novel evidence. The results were distinct in the group and treatment levels. The results showed that resveratrol has a role in angiogenesis in obesity and contributed to AdM production. It is observed that AdM has regulated its expression and increased the effect of resveratrol in WAT. AdM and VEGF-A gene expressions could not be detected in BAT; however, it is suggested that resveratrol may have a pro-angiogenic effect in BAT of obese rats according to the protein levels. AdM also has regulated VEGF-A level according to the metabolic situation of the organism.

中文翻译：

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肾上腺髓质素在肥胖雌性大鼠脂肪组织中白藜芦醇的血管生成作用中起作用。

肥胖是一种复杂的慢性疾病，它是根据遗传因素与环境因素之间的相互作用而产生的。白色脂肪组织（WAT）的扩张和生长可能与血管生成有关。白藜芦醇和肾上腺髓质素（AdM）用于抑制代谢被动WAT中的血管生成以抑制该组织的扩张，并激活代谢活跃的棕色脂肪组织（BAT）中的血管生成的激活以增加日常能量消耗，以减轻肥胖。 。将大鼠分为八组。四个肥胖组接受了以60％脂肪作为能量的高脂饮食三个月。获得肥胖后，每隔一天腹膜内（ip）将2.5 nmol / kg AdM和10 mg / kg白藜芦醇治疗至实验组，持续4周。半定量PCR检测AdM和血管内皮生长因子A（VEGF-A）mRNA水平。用蛋白质印迹法检测蛋白质水平。AdM和白藜芦醇是多因素分子，因此，这项研究揭示了一些新颖的证据。结果在组和治疗水平上是不同的。结果表明，白藜芦醇在肥胖症的血管生成中具有作用，并有助于AdM的产生。观察到AdM已调节其表达并增加了白藜芦醇在WAT中的作用。在BAT中无法检测到AdM和VEGF-A基因表达；然而，建议白藜芦醇根据蛋白质水平在肥胖大鼠的BAT中可能具有促血管生成作用。AdM还根据生物的代谢情况调节了VEGF-A的水平。