MicroRNAs are a class of small non-coding RNAs that are 19-22 nucleotides in length and regulate a variety of biological processes at the post-transcriptional level. MicroRNA dysregulation disrupts normal biological processes, resulting in tumorigenesis. Acute myeloid leukemia is an invasive hematological malignancy characterized by the abnormal proliferation and differentiation of immature myeloid cells. Due to the low 5-year survival rate, there is an urgent need to discover novel diagnostic markers and therapeutic targets. In recent years, microRNAs have been shown to play important roles in hematological malignancies by acting as tumor suppressors and oncogenes. MicroRNAs have the potential to be a breakthrough in the diagnosis and treatment of acute myeloid leukemia. In this review, we summarize the biology of microRNAs and discuss the relationships between microRNA dysregulation and acute myeloid leukemia in the following aspects: signaling pathways, the abnormal biological behavior of acute myeloid leukemia cells, the clinical application of microRNAs and competing endogenous RNA regulatory networks.

中文翻译：

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MicroRNA：急性髓细胞性白血病的关键调节剂。

MicroRNA是一类小的非编码RNA，其长度为19-22个核苷酸，并在转录后水平上调节多种生物学过程。MicroRNA失调会破坏正常的生物学过程，导致肿瘤发生。急性髓细胞性白血病是一种侵入性血液系统恶性肿瘤，其特征在于未成熟髓样细胞的异常增殖和分化。由于5年生存率低，迫切需要发现新的诊断标记和治疗靶标。近年来，微小RNA已经显示出通过充当肿瘤抑制物和癌基因而在血液恶性肿瘤中起重要作用。MicroRNA在急性髓细胞白血病的诊断和治疗中具有突破性的潜力。在这篇评论中