Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.

清道夫受体 B 类 I 型 (SR-BI) 蛋白是一种完整的膜糖蛋白。SR-BI 正在成为一种多功能蛋白，可调节自噬、胞吐作用、细胞存活和炎症。众所周知，SR-BI 通过介导胆固醇酯的选择性摄取和游离胆固醇的双向流动在脂蛋白代谢中起关键作用。最近，SR-BI 也被确定为癌症诊断、预后甚至治疗靶点的潜在标志物。天然产物是发现新药先导的有前途的来源。确定了多种天然产物来调节 SR-BI 蛋白表达。在调节癌症中的 SR-BI 表达和使用天然产物调节这种蛋白质表达方面仍然存在许多挑战。在本次审查中，