Abstract Aggregation of proteins is involved in many disorders. Besides amyloid fibrils, which mostly form in the brain, other kind of protein aggregates can lead, for example, to clots in the blood or floaters in the vitreous of the eye. This review aims to overview on how nanomaterials could be employed to avoid and destroy most diverse protein aggregates. Indeed, thanks to their recognized versatility, (stimuli-responsive) nanomaterials may offer attractive features against harmful protein aggregates. However, despite the many conceptually interesting strategies it appears that most important information on both the in vivo efficacy and safety of nanotechnology based prevention or destruction of protein aggregates, which is highly needed to pave the way to clinically relevant therapies, remains missing.

中文翻译：

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纳米材料避免和破坏蛋白质聚集体

摘要 蛋白质的聚集与许多疾病有关。除了主要在大脑中形成的淀粉样蛋白原纤维之外，其他种类的蛋白质聚集体也会导致例如血液中的凝块或眼睛玻璃体内的飞蚊症。本综述旨在概述如何使用纳米材料来避免和破坏大多数不同的蛋白质聚集体。事实上，由于其公认的多功能性，（刺激响应）纳米材料可以提供针对有害蛋白质聚集体的有吸引力的特性。然而，尽管有许多概念上有趣的策略，但似乎关于基于纳米技术的蛋白质聚集体预防或破坏的体内功效和安全性的最重要信息仍然缺失，这是为临床相关疗法铺平道路所必需的。