Abstract Recently the core-shell nanostructures are employed for various applications. In this trend, ϵ-Fe3N@Fe3O4 (INIO) magnetic nanoparticles (core/shell structured) were synthesized by a solvothermal process followed by calcination. The X-ray diffraction (XRD), selected area diffraction pattern (SAEDP), X-ray photoelectric spectroscopy (XPS) and Mossbauer spectroscopy validates the formation of the spherical core-shell structure of the ϵ-Fe3N@Fe3O4 nanoparticles having size range (5–32 nm). The saturation magnetization values for the sample at ±2 T field were around 128 and 99 Am2/kg at 5 and 300 K respectively. The values were higher than the known values for iron oxide nanoparticles. The pluronic acid (F-127) based ferrofluid of these nanoparticles, displayed excellent stability (Zeta potential values) and good heating ability (external AC magnetic fields). The best specific loss power was found to be around 90 W/g at 23 mT field. The cell viability with human lung adenocarcinoma A549 cells was observed to be 88 and 85% at 1 mg/mL for these nanoparticles after the treatment for 24 and 48 h respectively.

中文翻译：

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用于生物应用的ɛ-Fe3N@Fe3O4纳米颗粒的物理和体外评估

摘要 最近，核壳纳米结构被用于各种应用。在这种趋势下，ϵ-Fe3N@Fe3O4 (INIO) 磁性纳米粒子（核/壳结构）是通过溶剂热法和煅烧合成的。X 射线衍射 (XRD)、选区衍射图 (SAEDP)、X 射线光电光谱 (XPS) 和穆斯堡尔光谱验证了具有尺寸范围的 ϵ-Fe3N@Fe3O4 纳米颗粒的球形核壳结构的形成（ 5–32 纳米）。样品在 ±2 T 场下的饱和磁化值在 5 和 300 K 时分别约为 128 和 99 Am2/kg。这些值高于氧化铁纳米颗粒的已知值。这些纳米颗粒的基于聚醚酸 (F-127) 的铁磁流体，显示出优异的稳定性（Zeta 电位值）和良好的加热能力（外部交流磁场）。发现最佳比损耗功率在 23 mT 场下约为 90 W/g。在这些纳米颗粒分别处理 24 和 48 小时后，观察到这些纳米颗粒在 1 mg/mL 时与人肺腺癌 A549 细胞的细胞活力分别为 88% 和 85%。