Abstract Zirconia substituted 1393 bioactive glass and hydroxyapatite containing biocomposite were synthesized and sintered to investigate their effect on bioactivity and cell proliferation. The substituted bioactive glass was synthesized by the sol-gel method. Afterward, hydroxyapatite (synthesized by co-precipitation method) was mixed with bioglass in different ratios and sintered at two temperatures (600 °C and 1000 °C) to study the effect on phase, bioactivity, cell proliferation, and mechanical strength. In terms of bioactivity, biocomposites show dissolution and apatite formation in SBF. An increase in density and compressive strength was observed due to the incorporation of glass with hydroxyapatite. Cell proliferation was studied by MTT assay over MG63 cell lines and results indicate that an increase in sintering temperature promotes cell proliferation and found maximum for BG_H80 (sintered at 600 °C) and BG_H50 (sintered at 1000 °C). Due to an increase in sintering temperature crystallization in composites improved the density, compressive strength and cell proliferation and became suitable material for biomedical application.

中文翻译：

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含1393生物活性玻璃氧化锆与羟基磷灰石生物复合材料的合成、表征、力学和生物学性能

摘要 合成并烧结氧化锆取代的1393生物活性玻璃和含羟基磷灰石的生物复合材料，研究它们对生物活性和细胞增殖的影响。采用溶胶-凝胶法合成了取代的生物活性玻璃。然后，将羟基磷灰石（通过共沉淀法合成）与生物玻璃以不同比例混合并在两个温度（600°C 和 1000°C）下烧结，以研究对相、生物活性、细胞增殖和机械强度的影响。在生物活性方面，生物复合材料在 SBF 中显示出溶解和磷灰石形成。由于玻璃与羟基磷灰石的结合，观察到密度和抗压强度的增加。通过 MTT 测定对 MG63 细胞系进行细胞增殖研究，结果表明烧结温度的增加促进细胞增殖，并发现 BG_H80（在 600°C 下烧结）和 BG_H50（在 1000°C 下烧结）的最大值。由于复合材料中烧结温度的提高，结晶提高了密度、抗压强度和细胞增殖，成为适合生物医学应用的材料。