Little is known about the prevalence, presentation and management of calcific mitral valve disease (CMVD). We identified 167 patients (80 ± 10 years; 79% women) with significant CMVD undergoing transthoracic echocardiography at our institution in 2016. Patients presented with significant co-morbidities, 47% had moderate/severe mitral stenosis, 38% had 3+/4+ mitral regurgitation and 15% had a combination of both. Fifty-eight percent were symptomatic. Most symptomatic patients were managed conservatively and incurred higher mortality and mortality/heart failure admission rates than those managed surgically. These data highlight the importance of gaining mechanistic insights into CMVD to prevent its occurrence and avoid the need for high-risk surgery, which is seldom performed in contemporary practice.

中文翻译：

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钙化性二尖瓣疾病的表现和治疗。

关于钙化性二尖瓣疾病（CMVD）的患病率，表现和治疗知之甚少。我们在2016年确定了167例（80±10岁； 79％为女性）经胸腔超声心动图检查的严重CMVD患者。合并症明显的患者中，47％患有中度/重度二尖瓣狭窄，38％患有3 + / 4 +二尖瓣关闭不全和15％合并了两者。58％有症状。大多数有症状患者接受保守治疗，其死亡率和死亡率/心力衰竭住院率均高于手术治疗患者。这些数据突显了获得对CMVD的机械洞察力的重要性，以防止其发生并避免需要高风险手术，而这在现代实践中很少进行。